99% Purity Azd3759 CAS: 1626387-80-1 for Treatment of Cancer

Model NO.: CAS: 1626387-80-1
Maximum Monomer Impurity: ≤0.5%
Total Impurities: ≤1.0%
Heavy Metal: ≤20ppm
Appearance: Light Yellow Powder
Trademark: NJBN
Transport Package: 50g/Foil Bag; 25kg/Drum
Specification: 50g/foil bag; 25kg/drum
Origin: China
HS Code: 000000
Model NO.: CAS: 1626387-80-1
Maximum Monomer Impurity: ≤0.5%
Total Impurities: ≤1.0%
Heavy Metal: ≤20ppm
Appearance: Light Yellow Powder
Trademark: NJBN
Transport Package: 50g/Foil Bag; 25kg/Drum
Specification: 50g/foil bag; 25kg/drum
Origin: China
HS Code: 000000
99% Purity AZD3759 CAS: 1626387-80-1 for Treatment of cancer

Quick Details of AZD3759 :
 
Product Name AZD3759
Synonyms AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb
CAS No. 1626387-80-1
Molecular Formula C22H23ClFN5O3
Molecular Weight 459.91
EINECS No. 1592732-453-0
Melting point 192.4 °C in Alcohol, Ester; 193.3 °C in Water
Water solubility Soluble in DMSO
Moisture ≤0.5%
Maximum monomer impurity ≤0.5%
Total impurities ≤1.0%
Heavy metal ≤20ppm
Appearance Light Yellow Powder
Purity 99% min
Quality Standard Enterprise standard
Packing 50g/foil bag;25kg/drum
Shipment EMS;DHL;FedEx;TNT;UPS
Delivery Time 4-7 Working Days
Payment terms T/T;Western Union;Money Gram;Bitcoin
Usage Treatment of central nervous system metastases lung cancer

99% Purity Azd3759 CAS: 1626387-80-1 for Treatment of Cancer

AZD3759 Descriptions:

AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. . AZD3759 inhibits EGFR phosphorylation with an IC50 of 7.2 nM. AZD3759 inhibited proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and EGFR mutant genes with IC50 of 7.7 nM and 7 nM, respectively, and had no activity on the proliferation of H838 cells.

AZD3759 Applications:

A phase 1 clinical trial of AZD3759 showed very good control activity of intracranial lesions. The dose of this drug was recommended to be 200mg or 300mg each time, twice daily. AZD3759 does not control extracranial lesions better than other EGFR-targeting drugs, but it has a greater advantage in the control of intracranial lesions.Patients with meningo-metastasis in this clinical trial can benefit from the treatment of AZD3759, and the 300 mg dose appears to be more likely to obtain greater control.

Our order process:
Step 1 Please tell me in what products you are interested including CAS number, quantities, and the destination country.
Step 2 You confirm all details and offer us purchase order.
Step 3 We offer the quotation of products and suitable shipping method for reference.
Step 4 You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc.
Step 5 We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h
Step 6 We offer after-sales service after you receive products.

Our competitive advantages:
Rich experience Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Wide range of export Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
High customs pass guaranteed Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
Fast leading time Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc
99% Purity AZD3759 CAS: 1626387-80-1 for Treatment of cancer

Quick Details of AZD3759 :
 
Product Name AZD3759
Synonyms AZD 3759;AZD3759;AZD-3759;(2R)-2,4-Dimethyl-1-piperazinecarboxylic acid 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester;HY-18750;azd3579;1-Piperazinecarboxylic acid, 2,4-dimethyl-, 4-[(3-chloro-2-fluorophenyl)amino]-7-methoxy-6-quinazolinyl ester, (2R)-;4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-yl (2R)-2,4-dimethylpiperazine-1-carb
CAS No. 1626387-80-1
Molecular Formula C22H23ClFN5O3
Molecular Weight 459.91
EINECS No. 1592732-453-0
Melting point 192.4 °C in Alcohol, Ester; 193.3 °C in Water
Water solubility Soluble in DMSO
Moisture ≤0.5%
Maximum monomer impurity ≤0.5%
Total impurities ≤1.0%
Heavy metal ≤20ppm
Appearance Light Yellow Powder
Purity 99% min
Quality Standard Enterprise standard
Packing 50g/foil bag;25kg/drum
Shipment EMS;DHL;FedEx;TNT;UPS
Delivery Time 4-7 Working Days
Payment terms T/T;Western Union;Money Gram;Bitcoin
Usage Treatment of central nervous system metastases lung cancer

99% Purity Azd3759 CAS: 1626387-80-1 for Treatment of Cancer

AZD3759 Descriptions:

AZD3759 is a potent, orally active, CNS-permeable EGFR inhibitor with IC50 of 0.3 nM, 0.2 nM, and 0.2 nM for EGFR (WT), EGFR (L858R), and EGFR (exon 19Del), respectively. . AZD3759 inhibits EGFR phosphorylation with an IC50 of 7.2 nM. AZD3759 inhibited proliferation of PC-9 and H3255 cells derived from the pEGFR pathway and EGFR mutant genes with IC50 of 7.7 nM and 7 nM, respectively, and had no activity on the proliferation of H838 cells.

AZD3759 Applications:

A phase 1 clinical trial of AZD3759 showed very good control activity of intracranial lesions. The dose of this drug was recommended to be 200mg or 300mg each time, twice daily. AZD3759 does not control extracranial lesions better than other EGFR-targeting drugs, but it has a greater advantage in the control of intracranial lesions.Patients with meningo-metastasis in this clinical trial can benefit from the treatment of AZD3759, and the 300 mg dose appears to be more likely to obtain greater control.

Our order process:
Step 1 Please tell me in what products you are interested including CAS number, quantities, and the destination country.
Step 2 You confirm all details and offer us purchase order.
Step 3 We offer the quotation of products and suitable shipping method for reference.
Step 4 You confirm the order and pay money 100% in advance and send us your contact information including contacting person,address,mobile number etc.
Step 5 We arrange the shipment according to your requirements and tracking number will be offered after confirming the payment within 24h
Step 6 We offer after-sales service after you receive products.

Our competitive advantages:
Rich experience Our company is a professional raw powder factory in China for over 10 years, all powders are factory directly supplying.
Wide range of export Our products have exported to Germany, Norway, Poland, Finland, Spain, UK, France, Russia, USA, Australia, Japan, Korea and many other countries, over 100kgs each month.
High customs pass guaranteed Professional team special for package and shipment and staring on tracking code 24hours for customs pass guaranteed. 100% pass to UK, Norway, Poland, Spain, USA, Canada, Brazil; 98% pass to Germany, Russia, Australia, New Zealand.
Fast leading time Most of powders are in stock, Chargeable samples are available, Could be shipped out within 24hours.
High quality, good price, fast and safety delivery Shipment by EMS ,FEDEX,DHL,TNT, UPS ,etc

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