Analysis of Application Prospects of HPMC Hollow Capsules

With the wide application of capsules, hollow capsule technology, which is an important part of it, has also been greatly developed. In recent years, many new products have emerged. Hypromellose (HPMC) hollow capsules are among the representatives.

According to experts, as a new type of safe hollow capsule, HPMC hollow capsules have obvious advantages compared with traditional capsules. First, the main raw material of traditional gelatin hollow capsules is gelatin, which is mainly derived from the bones of cattle and pigs. Skin and so on, the harm caused by animal diseases in recent years is showing an increasingly high development trend. The main raw material of HPMC Hollow Capsules is hypromellose, which is mainly extracted from short lint or specific wood fibers. It is entirely derived from plants and is currently widely used in the food and pharmaceutical industries. Loading. Second, the indicators are better controlled. Hypromellose and gelatin capsules use more stringent control of heavy metals than gelatin. The Hypromellose standard in the 2010 edition of the Pharmacopoeia was ≤20 ppm, whereas the capsule gelatin used was ≤30 ppm. The testing conducted by relevant agencies showed that none of the HPMC pesticide residues (97 items) exceeded the limit, and all the genetic tests were qualified. No heavy metals, arsenic salts, and mercury were detected. Third, the storage performance is stable. Gelatin Hollow Capsule storage environment requirements in the humidity of 35% to 65%, the temperature of 10 °C ~ 25 °C, beyond the temperature and humidity control requirements, gelatin hollow capsules are prone to brittle deformation and other phenomena, affect the use of capsules, and hollow HPMC The environmental requirements of the capsules are very relaxed, and any temperature environment with humidity below 65% can meet its storage requirements. Fourth, the chemical stability is higher. Gelatin hollow capsules contain an amino acid amino group, so it is easy to cross-link with the aldehyde group of the content and react with the carbonyl group-containing compound to generate a dark reaction with the compound, resulting in discoloration of the capsule powder. The capsules become brittle and the appearance is distorted, while hypromellose is a chemically inert substance that does not produce a cross-linking reaction and therefore has a very high stability.

In summary, HPMC hollow capsules are safer than gelatin hollow capsules in terms of raw material control and finished product quality control and production process control, and are now increasingly available in the international market. The favor of many people has become the preferred capsule for high-end health products and medicines. Its sales in the international market reach 20 billion tablets each year, and it grows at a rate of 20% to 30% every year. In China, HPMC hollow capsules are also produced by enterprises, but due to price reasons, they are not well known and recognized by the public. Industry experts predict that due to the excellent performance of HPMC hollow capsules, its application prospects will be very broad.