Release date: 2008-09-22
The US media, such as the Washington Post, recently reported on a study conducted by the University of Rochester Medical Center and the Institute of Spinal Diseases of Shanghai University of Traditional Chinese Medicine on the topic of "Scientists have discovered how osteoarthritis can damage cartilage." The study confirmed that excessive beta-catenin protein in the body causes articular cartilage destruction in patients with osteoarthritis, which is a mechanistic study that helps prevent and treat osteoarthritis.
It is understood that the cellular and molecular mechanisms of articular cartilage destruction during osteoarthritis remain unclear, although previous studies have recognized that beta-catenin may be involved in the pathogenesis of osteoarthritis, but there has been no direct evidence to substantiate it. A Chinese-American scientific research team led by Dr. Chen Dezhi, a Chinese-American scientist and Dr. Tang Dezhi from the Institute of Spinal Diseases of Shanghai University of Traditional Chinese Medicine, established a mouse model of osteoarthritis genetic engineering. In the study, they found that most of the articular cartilage in mice was severely damaged, and bone spurs and tiny fractures similar to humans occurred. These findings suggest that activation of the β-catenin signal in articular chondrocytes prevents chondrocyte differentiation and maturation, forming an osteoarthritis-like phenotype. This study provides direct and unequivocal evidence for the pathogenesis of osteoarthritis.
Source: China Medicine 123 Network
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