Rapid propagation of plants is a matter of great concern to people of all ages. In 1902, German famous botanist Haberlandt proposed that plant cells have pluripotency and can be cultivated in vitro to become a complete plant, guiding the numerous researchers at home and abroad to begin climbing new scientific peaks. In 1958, fcsteward used carrot root cells to cultivate complete plants, flowering and fruitful, and achieved major breakthroughs, laying an important foundation for plant tissue culture technology procedures. This has brought about important advances in a wide range of disciplines including plant morphology, cells, physiology, biochemistry, genetics, asexual rapid propagation, breeding, agriculture, forestry, horticulture, and medicine. At home and abroad have been used for the rapid propagation of high-value flowers, fruit trees, vegetables, oil, landscaping seedlings, food crops and valuable Chinese herbal medicines, and rapid propagation of some seedlings has entered the stage of factory production. However, over the past 40 years, vegetative propagation seedlings that are most urgently needed, large, and low-cost in production have been faced with a one-time investment in plant tissue culture, high costs, and complicated technical steps. Poor susceptibility, farmers can not be directly used in production, plant survival rate of test tube clones is low, difficult to promote and other shortcomings, the test tube cloning technology in the actual rapid propagation of seedlings in the production of the productivity is still quite limited, the real formation of a large-scale industry The number of plant species in the world does not exceed 100. Up to now, there have been many achievements in the laboratory, and most of the production techniques of fast-producing varieties are still in the hands of scientists. Few projects have truly achieved industrialization goals. Although innumerable scientists have made arduous and remarkable efforts to reduce costs, simplify processes, and increase propagation coefficients for decades, people still cannot make plant tissue culture techniques for many rapid propagation of woody plants and tissue culture of conifers ( Tissue culture translates into enormous productivity on a large scale. Scientists in China have made great efforts to use plant tissue culture technology. Many plants have been successfully researched and can be rapidly propagated. However, only about 10 kinds of economic plants form a production line and are popularized in large areas, and the development speed is relatively slow. Traditional nursery techniques such as cuttings, grafting, layering, and ramets have been used for nearly 2000 years in human history. They are still being used at home and abroad. As a method of asexual propagation, the number of seedlings currently produced worldwide using this type of technology is the largest. The reason is that it has a long history, simple technology, the largest number of people engaged in production, and easy promotion. Its advantages also determine its long service life. However, it suffers from slow propagation, low production generation per year, and can not be industrialized for continuous production. It has not been resolved for a long time.
The plant non-tube high-efficiency rapid propagation technology (TERNPC) uses many plant-like microincubation material units (including one leaf and one bud) of 3 mm to 1 cm in length cultivated in the stem and apices of the test tube, and is directly inoculated with the aid of simple conditions. On the Datian sand bed, most of the economic plant explants were regenerated into complete plants 4 to 11 days after the second generation, and the survival rate was as high as 85% to 100%. Progeny breeds every 15 to 60 days and can be quickly and efficiently reproduced by geometric progression. The propagation coefficient is above 2-15, which is higher than the rapid propagation coefficient of many plants in vitro. Under the condition of completely leaving the plant tissue and cultivating various complicated equipments, a variety of plants can achieve efficient and rapid propagation under test tube conditions. The plant non-tube high-efficiency rapid propagation technology (TERNPC) has been developed, produced and promoted for various climatic zones and various soils throughout the country for 18 consecutive years. It has formed a complete technical system and is a very mature technology. Due to adopting a series of effective standardized technical measures and management experience, hundreds of thousands of specially trained general staff can be directly implemented in the field under simple conditions, which enhances the susceptibility and popularity of rapid propagation technology. The actual comprehensive rapid propagation efficiency is enhanced, and the production cost of factory plant nursery is minimized. One-time fixed investment is dozens of times lower than tissue culture rapid propagation technology. This technology perfectly and wisely overcomes all the shortcomings of plant tissue culture tube propagation and conventional nursery techniques, and retains and exploits all the advantages of both of them. When reaching a certain scale of nursery, the investment ratio of production can reach 1:5 to 1:10. It is very economizing on plant germplasm materials, and it only begins to multiply for most plants using 3 mm-1 cm long micropropagative material units (including one leaf and one bud), and can produce hundreds of thousands or even tens of millions in continuous production for one year. Purebred clone seedlings.
Palbociclib is a drug for the treatment of ER-positive and HER2-negative breast cancer developed by Pfizer. It is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6.
It was reviewed and approved under the Food and Drug Administration`s (FDA) accelerated Priority Review and Breakthrough Therapy designation programs on February 3, 2015 as a treatment (in combination with letrozole) for patients with estrogen receptor positive advanced breast cancer.
We produce a series of complete intermediates for Palbociclib, intermediate I (CAS No. 571188-59-5), intermediate II (CAS No. 1013916-37-4) and intermediate III (CAS No. 1016636-76-2) etc.
All of our products are with stable production and strict quality control, making sure your experience with Sunshine Biotech is always enriching, satisfying and fulfilling.
Palbociclib Intermediates,Cas 571188-59-5,Cas 1013916-37-4,Cas 1016636-76-2
Nanjing Sunshine Biotech Co., Ltd , http://www.sunshine-bio.com