[China Pharmaceutical Network Technology News] Toxins can not kill people but can cure people? Do you believe? Anyway, I believe! Columbia University data scientists have grown interest in the value of animal venom treatment, creating a known animal toxin The first catalogue of its physiological effects on humans, the world's first medical venom database, was created.
VenomKB, referred to as the venom knowledge base, summarizes the results of 5,117 medical literature describing toxins as painkillers and as a treatment for diseases such as cancer, diabetes, obesity, and heart failure. From the automatic analysis of the literature, the VenomKB library records that various venoms have nearly 42,723 effects on the human body. Although modern medicine has so far only utilized a small portion of the toxins recorded, the researchers hope that this catalogue will stimulate the discovery of new compounds and treatments.
"Based on this list we can take stock of the known venom and therapeutic effects," said Tatonetti, an assistant professor of biomedical informatics at Columbia University Medical Center and a member of the Institute of Data Science. “The question now is: How do we use this information to find new compounds and treatments with other databases?â€
Tatonetti is Romano's thesis supervisor. They searched the 22 million medical research papers in the term “venom/therapeutic use†and found 5,117 venom-related studies. They summarized the results using computer algorithms. . After cross-referencing toxins and multiple drugs and correcting irregularities in other data, they found 42723 venoms with specific effects on the body. Their findings were published in a journal related to the study of VenomKB, Scientific Data.
The healing power of venom is in contradiction with its rapid and deadly effects in the wild. Researchers have found in more than 173,000 species that venom has evolved over millions of years to act on disease-related molecules.
By mimicking or changing how these toxins act on specific human cells, researchers can develop drugs that suppress pain or treat diseases that often have fewer side effects than drugs already on the market.
According to a 2013 report by National Geographic magazine: To date, researchers have developed more than a dozen major drugs in accordance with the above strategy. The first to develop was an anticoagulant called Alvin. After a doctor discovered a snake venom protease in the late 1960s, Alvin was favored. Alvin is a purified part of the Malayan snake venom, used as an anticoagulant in thromboembolic diseases to treat blood clots in the legs.
The drug, widely used in type 2 diabetes, is made from the toxin exenatide in the saliva of the American and Mexican native poison lizards.
Another drug, bombesin, can treat gastrointestinal dysfunction, which is derived from toxins in the skin of European fireflies.
The researchers conducted clinical trials of five compounds produced by toxic conical snails, including ziconotide, an analgesic similar to morphine.
In the 5117 articles of VenomKB, the literature of Malayan python, poison iguana, European fire-bellied scorpion and conical snail accounted for about 18%. However, there are still 10 million and more toxic species to be studied. Zoltan Takacs, a toxicologist and Ph.D. in evolutionary research at Columbia University, estimates that there are still 20 million toxins waiting to be screened.
VenomKB was established during Romano and Tatonetti's drug application studies on venom. The instructor suggested that Romano look for a venom database. To their surprise, not to mention the database, even a venom directory could not be found. So they simply built a venom database VenomKB. Although VenomKB is currently small, VenomKB will be more valuable as researchers provide more data. Romano said, "With a database large enough, we can filter more effective and safer compounds."
Databases of compounds and their biological effects have been used in recent years to discover and develop new drugs, and to identify problems with the drugs being used. Tatonetti and his colleagues unearthed a federal database of drug side effects, the FDA Adverse Event Reporting System (FAERS), which found that the interaction of the antidepressant paroxetine and prasugat sold by the paroxetine brand increased diabetes. Blood sugar level.
With the launch and operation of VenomKB, Tatonetti and Romano plan to contribute their own data. Starting with dry venom samples from Black Mamba, they will experiment and explore new ways to treat chronic pain, diabetes and heart disease.
VenomKB, referred to as the venom knowledge base, summarizes the results of 5,117 medical literature describing toxins as painkillers and as a treatment for diseases such as cancer, diabetes, obesity, and heart failure. From the automatic analysis of the literature, the VenomKB library records that various venoms have nearly 42,723 effects on the human body. Although modern medicine has so far only utilized a small portion of the toxins recorded, the researchers hope that this catalogue will stimulate the discovery of new compounds and treatments.
"Based on this list we can take stock of the known venom and therapeutic effects," said Tatonetti, an assistant professor of biomedical informatics at Columbia University Medical Center and a member of the Institute of Data Science. “The question now is: How do we use this information to find new compounds and treatments with other databases?â€
Tatonetti is Romano's thesis supervisor. They searched the 22 million medical research papers in the term “venom/therapeutic use†and found 5,117 venom-related studies. They summarized the results using computer algorithms. . After cross-referencing toxins and multiple drugs and correcting irregularities in other data, they found 42723 venoms with specific effects on the body. Their findings were published in a journal related to the study of VenomKB, Scientific Data.
The healing power of venom is in contradiction with its rapid and deadly effects in the wild. Researchers have found in more than 173,000 species that venom has evolved over millions of years to act on disease-related molecules.
By mimicking or changing how these toxins act on specific human cells, researchers can develop drugs that suppress pain or treat diseases that often have fewer side effects than drugs already on the market.
According to a 2013 report by National Geographic magazine: To date, researchers have developed more than a dozen major drugs in accordance with the above strategy. The first to develop was an anticoagulant called Alvin. After a doctor discovered a snake venom protease in the late 1960s, Alvin was favored. Alvin is a purified part of the Malayan snake venom, used as an anticoagulant in thromboembolic diseases to treat blood clots in the legs.
The drug, widely used in type 2 diabetes, is made from the toxin exenatide in the saliva of the American and Mexican native poison lizards.
Another drug, bombesin, can treat gastrointestinal dysfunction, which is derived from toxins in the skin of European fireflies.
The researchers conducted clinical trials of five compounds produced by toxic conical snails, including ziconotide, an analgesic similar to morphine.
In the 5117 articles of VenomKB, the literature of Malayan python, poison iguana, European fire-bellied scorpion and conical snail accounted for about 18%. However, there are still 10 million and more toxic species to be studied. Zoltan Takacs, a toxicologist and Ph.D. in evolutionary research at Columbia University, estimates that there are still 20 million toxins waiting to be screened.
VenomKB was established during Romano and Tatonetti's drug application studies on venom. The instructor suggested that Romano look for a venom database. To their surprise, not to mention the database, even a venom directory could not be found. So they simply built a venom database VenomKB. Although VenomKB is currently small, VenomKB will be more valuable as researchers provide more data. Romano said, "With a database large enough, we can filter more effective and safer compounds."
Databases of compounds and their biological effects have been used in recent years to discover and develop new drugs, and to identify problems with the drugs being used. Tatonetti and his colleagues unearthed a federal database of drug side effects, the FDA Adverse Event Reporting System (FAERS), which found that the interaction of the antidepressant paroxetine and prasugat sold by the paroxetine brand increased diabetes. Blood sugar level.
With the launch and operation of VenomKB, Tatonetti and Romano plan to contribute their own data. Starting with dry venom samples from Black Mamba, they will experiment and explore new ways to treat chronic pain, diabetes and heart disease.
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