Japanese researchers successfully replicated the world's first pig "Xena" using pig fetal cells.
The birth of "Xena" highlights the potential for transforming cellular genes for xenotransplantation.
This will allow pigs to become genetically modified organs for donors transplanted to humans. The human body usually repels porcine organs.
"The next step in replicating pigs - the researchers hope to make xenotransplantation a viable option - will be to transform the genes used to replicate the pig's cells," said the chief scientist at the National Institute of Animal Industry in Japan.
The "Xena" method of replication is this: a needle-like tubule is quickly but controlledly drilled into the egg, and the genetic material from the porcine superdermal cells is injected into its own genetic material by means of microscopy. The egg was removed.
One of the authors of the report, Perry of Rockefeller University, said: "With microinjection, you can choose gene transfer arbitrarily. You can separate the chromosomes and avoid contaminating the eggs with other substances that contribute to the nucleus."
The key to the success of "Xena" was the ability of researchers to rapidly implant genetic material. "Xena" is a replication of cells of a black pig breed. The researchers transplanted a total of 110 embryos to four sows, and "Xena" was the only crystalline product.
The scientists transplanted eggs after they were stimulated by electric pulses and matured into early embryos.
This method of replication was based on the method that Honolulu University scientists had successfully replicated mice two years ago.
It differs from the method used to replicate “Dolly†sheep, which mixes the entire donated cells containing genetic material with empty eggs.
Pig reproduction may also be a major step towards animal husbandry, which facilitates the preservation of carefully mated pig breeds and increases their fertility.
The birth of "Xena" highlights the potential for transforming cellular genes for xenotransplantation.
This will allow pigs to become genetically modified organs for donors transplanted to humans. The human body usually repels porcine organs.
"The next step in replicating pigs - the researchers hope to make xenotransplantation a viable option - will be to transform the genes used to replicate the pig's cells," said the chief scientist at the National Institute of Animal Industry in Japan.
The "Xena" method of replication is this: a needle-like tubule is quickly but controlledly drilled into the egg, and the genetic material from the porcine superdermal cells is injected into its own genetic material by means of microscopy. The egg was removed.
One of the authors of the report, Perry of Rockefeller University, said: "With microinjection, you can choose gene transfer arbitrarily. You can separate the chromosomes and avoid contaminating the eggs with other substances that contribute to the nucleus."
The key to the success of "Xena" was the ability of researchers to rapidly implant genetic material. "Xena" is a replication of cells of a black pig breed. The researchers transplanted a total of 110 embryos to four sows, and "Xena" was the only crystalline product.
The scientists transplanted eggs after they were stimulated by electric pulses and matured into early embryos.
This method of replication was based on the method that Honolulu University scientists had successfully replicated mice two years ago.
It differs from the method used to replicate “Dolly†sheep, which mixes the entire donated cells containing genetic material with empty eggs.
Pig reproduction may also be a major step towards animal husbandry, which facilitates the preservation of carefully mated pig breeds and increases their fertility.
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