Release date: 2016-05-20
Xinhua News Agency, Washington, May 18th, the Chinese team of Chinese scientists at the University of Texas, Shi Peiyong, recently successfully cloned Zika virus, which will help accelerate the development of Zika vaccine.
The researchers reported in a new issue of the journal Cell Hosts and Parasites that they selected clones isolated from Cambodia in 2010 for cloning. According to its genomic sequence, the viral gene components are first divided into five fragments, and then the fragments are cloned separately, and then the cloned products are assembled into a complete viral genome, and then the cloned genome is introduced into the cells by molecular biological methods, thereby obtaining clones. virus.
Mouse experiments have shown that cloning viruses can cause disease in mice, and they can develop symptoms of some neurological diseases, similar to the Zika virus that can cause neurological diseases in humans.
The researchers also conducted a mosquito-borne experiment to clone the virus. The results showed that the cloned virus has a propagation efficiency similar to that of the maternal virus.
The researchers said that the cloning of Zika virus helps to gain a deeper understanding of it, such as mutations at any site or any protein, to understand the pathogenesis of Zika virus and which proteins play an important role in disease.
The research team of Shi Peiyong said in an e-mail interview with Xinhua News Agency: "The acquisition of cloned virus provides an important tool for us to accelerate the understanding of Zika virus, and will accelerate the basic research and applied research on Zika virus. We hope to cooperate extensively with various laboratories. We are actively promoting cooperation with some research groups in China."
Source: Xinhua News Agency
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