Veterinary drug residues are now familiar words. In the past 20 years, improper use of veterinary drugs in animal husbandry has led to the retention or accumulation of drugs in animals and has entered the human body and ecosystem in a residual manner. Its harm to the human body and the environment is mainly chronic, long-term and cumulative, such as carcinogenic, affecting people's growth and development, destroying people's normal immune system, and making the body's pathogenic microorganisms produce drug resistance. It is gratifying that with the support of the National 863 Program, China has taken the lead in the international community to develop a biochip system for "screening" residual veterinary drugs. "Biochips integrate thousands of densely arranged molecular microarrays that can analyze a large number of biomolecules in a short period of time, enabling people to quickly and accurately obtain biological information in samples. The efficiency is the result of hundreds of traditional detection methods. Thousands of times, "said Xing Deli, deputy director of Boao Biology & Biochip Beijing National Engineering Research Center. Routine tests are inefficient and costly. Current routine veterinary drug residue detection methods are mainly physical and chemical analysis instrument methods. These methods have problems such as expensive equipment, cumbersome operation, and large reagent consumption. There are also some biological techniques used in the rapid detection of veterinary drug residues, such as microbial and ELISA. The microbiological detection method is low in cost, easy to operate, and has certain sensitivity. It has certain advantages in the simultaneous analysis of a large number of samples, but this method is slow in analysis, poor in specificity, and can only determine bioactive residues. The enzyme-linked immunoassay currently uses imported kits, which are expensive, and can only detect a single veterinary drug. "The biochip technology can play an important role in this area," said Xing Xing, deputy director. "The biochip is a thin, solid device that can process and analyze biomolecules quickly and in parallel. It has only the size of a fingernail, and the material is usually glass and silicon. Films, nylon membranes, plastics, etc. It can integrate the three steps of sample preparation, biochemical reaction and result detection.†Fast and efficient detection of biochips This set of veterinary drug residues protein immunoassay detection system is released by Boao Biosciences and Shanghai. Inspection and Quarantine Bureau, Beijing Entry-Exit Inspection and Quarantine Bureau, Yunnan Entry-Exit Inspection and Quarantine Bureau and other units jointly developed. Most veterinary drugs are small molecule chemicals. Before preparing chips, they must first obtain antibodies to veterinary drugs. At the time of detection, the veterinary drug sample in the food is extracted with a rapid extractor and mixed with an antibody on a chip. The antigen and antibody undergo a competitive immune reaction, and then detected by a laser confocal scanner. Finally, a specific software is used to automatically determine whether the residue is present. Excessive standards. “At present, this chip system has been able to detect several key veterinary drugs including clenbuterol, sulfamethazine and streptomycin. With the support of the Beijing Municipal Bureau of Agriculture, the chip system was already in Beijing in early 2004. Veterinary Drug Surveillance Laboratory trials.This set of chip system has a multi-indicator detection function, and sample extraction is quick and easy, which can shorten the entire analysis time by tens of times. It will provide an efficient and convenient platform for food safety screening.†Xing Xing, Deputy Director Say. In this area, as the national 863 project, Shaanxi Xida North America Gene Co., Ltd. is engaged in the development of other products. They have developed a microfluidic chip that can detect lean crust and flour brightener, benzoyl peroxide. system. Biochips will move toward tens of thousands of veterinary drug residues and detection is just an application of biochips. With the support of the National 863 Program, more achievements are gradually maturing and applying, such as pathogenic microorganism detection chips, tumor marker detection chips, tumor prognosis prediction chips, autoimmune disease detection chips, and stimulant detection chips. At present, China has 298 kinds of biochips and related products available. As of the end of 2004, the accumulated sales revenue of various types of biochips and related products independently researched and developed in China has exceeded 100 million yuan. Some people think that, in a sense, if the 20th century belongs to microelectronics chips, the 21st century is the era of biochips, it revolutionized the accuracy of medical diagnosis and treatment, and changed the way of life science research. Biochips are heading for millions of households and providing protection for human health will become a reality in the near future. Linked biochips are a highly cross-cutting new technology developed in the 1980s that integrates microelectronics, biology, physics, chemistry, and computer science. It refers to the use of light-guided in-situ synthesis or micro-spotting and other methods, a large number of biological macromolecules such as nucleic acid fragments, polypeptide molecules and even tissue sections, cells and other biological samples in an orderly manner to the support (such as slides, wafers, The surface of a polyacrylamide gel, a nylon membrane, etc., is composed of a dense two-dimensional array of molecules, which is then hybridized with the labeled target biological sample, and the intensity of the hybridization signal is measured by a specific instrument such as confocal laser scanning. Rapid, parallel, and efficient detection and analysis to determine the number of target molecules in the sample. It has a wide range of uses in disease diagnosis, drug development, and environmental testing. It has a huge market potential and has become one of the most important growth points and competition focuses in the international biotechnology industry. At the same time, because biochips are an emerging field, they are basically on the same starting line at home and abroad, providing China with tremendous opportunities for development.
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