"Your tumor makes you a prisoner of your own body, you can't sing, you can't dance, you can't even tell your family that you love us."
Professor Han Heyou
Catherine was diagnosed with a brain tumor in children in 2015. After a year of fighting the disease, she finally left her family with great grief. After Catherine's death, her family wrote down the process of her tears from diagnosis to death, hoping to have more money invested in brain tumor research, to increase the hope of survival for other cancer patients. Instead of leaving as early as Catherine.
Tumor "special effect drug"
Traditional drugs for treating tumors can kill cancer cells, but at the same time, they can kill normal cells and cause serious toxic and side effects, causing problems such as hair loss and low immunity in the process of tumor chemotherapy, which seriously affects the quality of life of patients, and patients suffer. Words.
“Is it possible to use the unique acidic microenvironment of cancer tissue to break through the bottleneck of cancer treatment?†Professor Han Heyou from the School of Science, Huazhong Agricultural University said: “Unlike normal human tissues, the proliferation of cancer cells is characterized by excessive and disordered growth. Its active glycolysis promotes the production of large amounts of acidic substances, resulting in a unique acidic microenvironment for cancer tissues. More importantly, the acidic microenvironment of the tumor is present in most cancer tissues."
Therefore, he led the nanobiochemistry group to use this feature to start research and construct acid-responsive peptide nanoparticles composed of a peptide with a nuclear localization function and a photosensitizer molecule, aiming at achieving drug utilization by improving drug utilization. Accurate treatment of cancer tissue.
In mouse in vivo experiments, the particles showed good stability and safety in the blood of mice. At the same time, the nanoparticles are also efficiently enriched in the tumor area of ​​mice.
In the fluorescence imaging results of small animals, the polypeptide nanoparticles have obvious fluorescence signals at the tumor, while the fluorescence signals are weaker at other positions in the body, showing a good "precise guidance" effect of the nanoparticles on the tumor. Moreover, the nanoparticles have a longer in vivo circulation time, thereby greatly improving the inhibitory effect on the tumor.
After repeated review of the literature, rigorous scientific research, the research results obtained by Professor Han Heyou's team laid a good foundation for the subsequent practical application, and also provided new ideas for tumor targeted therapy.
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