The 2016 Nobel Prize in Medicine was announced: the award of the Japanese scientist

According to the latest news of the Nobel Prize official website, at 11:30 on October 3, local time in Stockholm, Sweden, the 2016 Nobel Prize in Physiology or Medicine was announced at the Karolinska Institute in Sweden, and the Japanese molecular cell biologist Yoshinori Ohsumi won the award in recognition of his contribution to the study of autophagic lysosomes.

According to media reports, Otsuka Ryoden is currently a professor of molecular cytology at Tokyo Institute of Technology, Japan. The research team led by it announced in July this year that it successfully identified the initiation mechanism of autophagy. This study is important for the prevention and treatment of cancer and neurological diseases caused by autophagy.

In addition to the ability to decompose aging substances and harmful substances in cells and maintain good health, many autophagic mammals also use this phenomenon to regenerate the cells to maintain their lives. Professor Daxie used a microbial enzyme in the late 1980s to successfully observe the autophagy process in the cell, but the specific mechanism of this phenomenon has not been proven.

The 2016 Nobel Prize in Medicine was announced: the award of the Japanese scientist

Daxie Liangdian

This time, the panelists focused on the Atg13 protein that promotes autophagy. It was observed by experiments using yeast that Atg13 protein was linked to the other four proteins through a network structure to form a huge autophagy initiation device. This device creates a double membrane structure that absorbs only decomposing substances. The researchers said that the relevant mechanisms of the process will be further explored in the future.

[Research related multiple ailments]

In the 1960s, researchers first discovered the phenomenon of autophagy, that is, the cells themselves decomposed and recycled their own constituents.

Studies have found that disturbed autophagy processes are associated with a variety of conditions, including Parkinson's disease, diabetes, and cancer.

In the 1990s, Daxie Liangdian used yeast to discover genes essential for autophagy, revealing the basic mechanism of autophagy and its physiological significance.

Caroline Medical School commented that the study of the Daxie Liangdian "given a new model for understanding how cellular materials are recycled." "Autophagy mutations can cause disease, and autophagy processes are associated with a variety of conditions, including cancer and neurological diseases." With the results of the research by Otsuka and others, humans are actively developing drugs to treat the disease.

The 2016 Nobel Prize in Medicine was announced: the award of the Japanese scientist

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