Insufficient and Analyzed Tablet Presses in Domestic Tablet Process Equipment In addition to price and yield, the important factors that pharmaceutical manufacturers consider when selecting a tablet press are the quality of tablet drugs.
The tablet press has a dust problem during the tableting process, which is an urgent problem to be solved. At present, domestic high-speed rotary tablet presses and screen machines in the production of dust generated in the production, generally use a special vacuum cleaner to provide negative pressure to remove the suction. However, due to the gap between the existing technical level and the consciousness, the sealing effect of the equipment itself is not satisfactory, and some dust is still leaked to the purification area. In addition, the dust generated by the process of material conveying or tablet transfer may also be directly leaked from the relevant joint to the purification area.
The problem still exists in the tablet presses used by most small and medium-sized pharmaceutical companies, that is, the film machine is contaminated, the cleaning is difficult, the product cannot be detected online, and the equipment operation record is manually filled. Due to the limitations and defects of the equipment, it also brings many practical problems to the GMP management and product quality of the enterprise.
One of the main reasons for the contamination of the tableting machine is that the design of the lubrication system is unfair. The specificity of the pharmaceutical equipment is not fully considered. The lubrication of the equipment is largely liquid lubricant, and the sealing is not good, which often causes drug contamination. Equipment manufacturers can consider adding grease timing lubrication devices to the tablet press or adopting a reliable sealing method to reduce or eliminate lubricant contamination of the drug. Another major source of pollution is the poor sealing of the feeder and the rotating platform, causing dust pollution. British MANESTY uses a polyurethane seal ring structure without gap feeder, so that the bottom of the feeder and the middle mold of the turntable achieve zero gap contact, avoiding the defects of the current feeder on the seal.
Most domestic tablet presses are very difficult to clean and cannot be cleaned online. When cleaning, not only must the upper punch, the lower punch, and the middle die be removed, but also the dead corners that are difficult to remove and difficult to clear are also many. And some foreign presses can achieve fast loading and unloading and online cleaning. Even with a small number of tools and a small number of parts, you can quickly and easily assemble and disassemble parts that need to be cleaned. Some tablet presses also use a changeable turntable for quick cleaning. Domestic tablet presses should also be improved in this regard.
The main development direction of foreign tablet presses: production under the control and sealing conditions of intelligent and ultra-micro units. Some even use transmission equipment such as magnetic powder clutch and magnetic powder brake, which shows that the foreign tablet press has taken another step. There are nearly 30 manufacturers of tablet presses in China, and there are as many as five or six of them capable of producing high-speed tablet presses. However, due to the weak basic research, the lack of talents and the imperfect innovation mechanism, there is still a big gap with advanced foreign tablet presses and tableting technology.
The tablet press has a dust problem during the tableting process, which is an urgent problem to be solved. At present, domestic high-speed rotary tablet presses and screen machines in the production of dust generated in the production, generally use a special vacuum cleaner to provide negative pressure to remove the suction. However, due to the gap between the existing technical level and the consciousness, the sealing effect of the equipment itself is not satisfactory, and some dust is still leaked to the purification area. In addition, the dust generated by the process of material conveying or tablet transfer may also be directly leaked from the relevant joint to the purification area.
The problem still exists in the tablet presses used by most small and medium-sized pharmaceutical companies, that is, the film machine is contaminated, the cleaning is difficult, the product cannot be detected online, and the equipment operation record is manually filled. Due to the limitations and defects of the equipment, it also brings many practical problems to the GMP management and product quality of the enterprise.
One of the main reasons for the contamination of the tableting machine is that the design of the lubrication system is unfair. The specificity of the pharmaceutical equipment is not fully considered. The lubrication of the equipment is largely liquid lubricant, and the sealing is not good, which often causes drug contamination. Equipment manufacturers can consider adding grease timing lubrication devices to the tablet press or adopting a reliable sealing method to reduce or eliminate lubricant contamination of the drug. Another major source of pollution is the poor sealing of the feeder and the rotating platform, causing dust pollution. British MANESTY uses a polyurethane seal ring structure without gap feeder, so that the bottom of the feeder and the middle mold of the turntable achieve zero gap contact, avoiding the defects of the current feeder on the seal.
Most domestic tablet presses are very difficult to clean and cannot be cleaned online. When cleaning, not only must the upper punch, the lower punch, and the middle die be removed, but also the dead corners that are difficult to remove and difficult to clear are also many. And some foreign presses can achieve fast loading and unloading and online cleaning. Even with a small number of tools and a small number of parts, you can quickly and easily assemble and disassemble parts that need to be cleaned. Some tablet presses also use a changeable turntable for quick cleaning. Domestic tablet presses should also be improved in this regard.
The main development direction of foreign tablet presses: production under the control and sealing conditions of intelligent and ultra-micro units. Some even use transmission equipment such as magnetic powder clutch and magnetic powder brake, which shows that the foreign tablet press has taken another step. There are nearly 30 manufacturers of tablet presses in China, and there are as many as five or six of them capable of producing high-speed tablet presses. However, due to the weak basic research, the lack of talents and the imperfect innovation mechanism, there is still a big gap with advanced foreign tablet presses and tableting technology.
Guangdong Jia Mei Biological Technology Co.Ltd , https://www.jaymeimask.com