Malnutrition can affect invading microorganisms

Release date: 2007-08-10

Malnutrition can have a significant impact on the body's ability to fight off infections. When the host’s immune system is weakened due to poor nutrition, it becomes more vulnerable to invading microorganisms, which can lead to more severe and prolonged infections. Studies on RNA viruses, such as Coxsackie B and influenza, have shown that deficiencies in essential nutrients like selenium or vitamin E can worsen disease outcomes and even promote genetic mutations in the virus itself, increasing its virulence.

For instance, the variation seen in the H3N2 strain of the influenza virus is largely attributed to changes in the matrix protein M1, a component that is typically stable. Whether these changes result from selective pressures or directly influence viral RNA remains unclear. However, there are growing concerns about whether malnourished individuals infected with H5N1 might experience faster genetic evolution of the virus, leading to higher virulence and mortality rates.

Malnutrition not only weakens the host but may also contribute to more complex viral mutations, potentially facilitating the spread of the virus between people. These findings highlight the critical need to address global poverty and malnutrition, as they play a key role in shaping the dynamics of infectious diseases. The impact of nutritional status on pathogen behavior is an area that has been overlooked for too long, yet it holds great value for both human health and experimental research. By understanding this connection, we can develop better strategies to prevent and control outbreaks, especially in vulnerable populations. ——Midi Medical Network

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