Malnutrition can affect invading microorganisms

Release date: 2007-08-10

Malnutrition can significantly impact the body's ability to defend against invading microorganisms, making infections more severe and prolonged. Studies on RNA viruses, such as Coxsackie B and influenza, have shown that deficiencies in essential nutrients like selenium or vitamin E can worsen disease outcomes and lead to genetic mutations in the virus, increasing its virulence. For instance, the H3N2 influenza virus undergoes significant changes, particularly in the matrix protein M1, which is usually stable. These changes may either represent natural selection of existing mutations or directly influence the viral RNA in ways that are not yet fully understood. There is growing concern that malnourished individuals infected with highly pathogenic strains like H5N1 may experience accelerated genetic variation during infection, leading to increased virulence and higher mortality rates. Malnutrition could play a key role in generating complex mutations, potentially facilitating the spread of more dangerous viral strains. This connection highlights the critical need to address global poverty and malnutrition, as these factors can have far-reaching consequences on public health. Research in this area—though often overlooked—has the potential to provide important insights into how nutrition influences the behavior of pathogens and the immune response. Studying both human populations and experimental models in this context is essential for developing better strategies to prevent and control infectious diseases. ——Midi Medical Network

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