New use of Novartis antineoplastic drugs: significant anti-recurrent bone metastasis effect

Not long ago, at the seminar "Progress and Hot Spots of Cancer Bone Metastasis Research" held in Beijing, Peter Duschi, head of the Austrian Breast and Colorectal Cancer Research Group, announced a new study of European Zui, Novartis AG The selected Zhaitai has a significant anti-tumor effect on early breast cancer patients with premenopausal hormone receptor-positive. The study found that the addition of Xingtai to endocrine therapy after surgery reduced the risk of primary tumor recurrence by 36% compared with endocrine therapy alone.
In various advanced tumor patients, about 20%-30% of the tumor cells will spread to the bone tissue of the distant focal organ, thereby forming bone metastasis. This is especially true for patients with lung, breast and prostate cancer. In addition to conventional chemotherapy, radiotherapy and isotope treatment, bisphosphonates have become the drug of choice worldwide for the treatment of bone metastases. Zeta is the only bisphosphonate approved globally for the treatment of various tumor bone metastases.
In the case of breast cancer, the recurrence is related to estrogen. Endocrine therapy can reduce estrogen levels, which accelerates bone loss in premenopausal and postmenopausal women, decreases bone density, and increases the risk of fracture. A total of 1,803 premenopausal, estrogen and progesterone receptor-positive breast cancer patients participated in the study. At the same time as endocrine therapy, the researchers added Kate to the patients to see if this would prolong the patient's disease-free survival and reduce tumor recurrence. The results showed that the local recurrence, distant metastasis, and contralateral breast cancer risk were lower in patients who received the Zhaitai group, indicating and confirming the anti-tumor effect of Zhaitai.
The participating experts, Professor Xu Binghe, director of the Department of Internal Medicine of the Chinese Academy of Medical Oncology Hospital, and Professor Zhang Li, from the Cancer Hospital of Sun Yat-sen University, all commented that this is a major discovery in the world medical community this year. There will be similar studies in the future, including lung cancer, breast cancer and prostate cancer, all of which are doing anti-tumor research.
At present, a large number of medical tests have confirmed that Zhaitai has significant effects on bone metastasis of breast cancer, lung cancer, prostate tumor and other solid tumors, and multiple myeloma bone destruction. Zhaitai was therefore approved by the US FDA as the only bisphosphonate drug effective for bone metastases of various solid tumors and multiple myeloma, and is safe to use and convenient to administer.

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