German researchers have announced that they have identified the pathogenesis of acute lung injury associated with blood transfusions and have found ways to prevent this fatal blood transfusion. The research results have been published in Zui's new issue of Nature Medicine.
Andreas Greinah, a professor at the University of Greifswald in Germany, said that his team first discovered a hitherto unknown blood group protein on human leukocytes and identified its molecular structure. When transfusion of blood to a patient, if the blood donor contains HNS-3a-specific antibodies, the antibody often binds to the blood group protein of the recipient, causing leukocyte deformation and adhesion, blocking the microvessels of the lungs, resulting in acute lungs. damage.
Since the molecular structure of the above blood group proteins was ascertained and related genes were found, the researchers artificially cultured a large number of such blood group proteins. The blood test based on this blood group protein can be used to detect which blood donors contain HNS-3a-specific antibodies, thereby preventing acute lung injury associated with blood transfusion. He also said that this special blood test can be put into clinical use in about a few months.
Andreas Greinah, a professor at the University of Greifswald in Germany, said that his team first discovered a hitherto unknown blood group protein on human leukocytes and identified its molecular structure. When transfusion of blood to a patient, if the blood donor contains HNS-3a-specific antibodies, the antibody often binds to the blood group protein of the recipient, causing leukocyte deformation and adhesion, blocking the microvessels of the lungs, resulting in acute lungs. damage.
Since the molecular structure of the above blood group proteins was ascertained and related genes were found, the researchers artificially cultured a large number of such blood group proteins. The blood test based on this blood group protein can be used to detect which blood donors contain HNS-3a-specific antibodies, thereby preventing acute lung injury associated with blood transfusion. He also said that this special blood test can be put into clinical use in about a few months.
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