A groundbreaking study conducted by Queen's University in Canada has uncovered the role of a specific cellular enzyme in causing tissue damage following a heart attack or stroke. This discovery opens new pathways for developing targeted drug therapies that could improve recovery after such events, while also offering potential benefits for conditions like Alzheimer's and other neurodegenerative diseases.
The research team, led by Canadian protein engineering professor Peter Davies, emphasized the significance of their findings. "This is really exciting," Davies said. "Understanding the structure of this protein and how its inhibitors work without harming the cells has been a long-standing challenge."
Calpain, a type of remodeling protein involved in cell growth and movement, plays a key role in helping cells detach from other proteins. However, when calcium ion levels rise abnormally—often due to the sudden return of blood flow after a heart attack or stroke—calpain becomes overactive. This leads to severe tissue damage. Rob Campbell, a member of the research team, explained, "People don’t want the enzyme to be activated uncontrollably, nor do they want it completely shut down."
In addition to calpain, the study explored the role of calpastatin, another protein that helps regulate calpain activity. When calcium ions are present, calpastatin becomes active and inhibits calpain. Through their research, Campbell and Ph.D. student Rachel Hanna successfully mapped the structure of calcium-bound calpain and revealed how calpastatin prevents its harmful effects without being destroyed itself.
This breakthrough provides critical insights that could lead to the development of more effective drugs to protect tissues from damage caused by excessive calpain activity. The findings not only advance our understanding of cellular mechanisms but also bring us one step closer to better treatments for major health issues like strokes, heart attacks, and neurodegenerative diseases.
Lighting Parts
This classification mainly includes the aluminum or zinc alloy die casting parts using in Lighting area.
In the die casting process,higher specific pressure is required, so that higher filling speed can be obtained.which is beneficial for alloy to overcome mold filling resistance.and effectively fill each part of the cavity.The Casting General Tolerance is Grade GB-CT4.
Process Technology: High pressure die casting, Cold Chamber
Product Dimensions: Customized
Casting General Tolerance: Grade GB-CT4
Flow Processes: Die casting, Degating to remove the residual of the gate, Polishing and Deburring to remove the burrs, Polishing to remove the parting line, flash,CNC Turning, Cleaning, Packaging, Storaging, Shipping
Control Measure: Incoming Material Test, First Article inspection, Routing inspection, Final item inspection, and Outgoing quality control
Inspection Equipment: CMM, Caliper, Plug Gage, Screw Gauge
Application: Machinery Parts
Certificate: IATF16949:2016,ISO14001:2015,ISO45001:2018
Lead Time: 30-35 days
Trade Term: FOB Ningbo
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