A groundbreaking study conducted by Queen's University in Canada has uncovered the role of a specific cellular enzyme in causing tissue damage following a heart attack or stroke. This discovery opens new pathways for developing innovative drug therapies aimed at improving recovery after such events, while also offering potential benefits for reducing the impact of Alzheimer’s and other neurodegenerative diseases.
The research team, led by Professor Peter Davies from the Department of Biochemistry and Biomedical Sciences, expressed excitement over their findings. "This is really exciting because the structure of this protein and how its inhibitors stop it from acting without harming the cell itself has been a mystery for a long time," Davies said.
Calpain, a type of remodeling protein involved in cell growth and movement, helps cells detach from other proteins. However, when calcium ion levels rise abnormally—often due to interrupted blood flow during a heart attack or stroke—calpain becomes overactive. Upon reperfusion, when blood returns to the affected area, a sudden influx of calcium can lead to severe tissue damage.
Rob Campbell, a member of the research team, explained, "People don’t want the enzyme to be either fully activated or completely shut down. It needs to be carefully regulated."
The study also revealed how calpastatin, another protein, interacts with calpain. When calcium ions activate calpastatin, it binds to calpain and inhibits its activity without being destroyed in the process. Through advanced imaging techniques, Campbell and Ph.D. student Rachel Hanna were able to map the structure of calcium-bound calpain and understand the mechanism of inhibition.
This breakthrough could pave the way for new drugs that specifically target calpain's overactivity, potentially minimizing tissue damage and improving patient outcomes after cardiovascular events and neurological conditions.
LED Underwater Light
This classification mainly includes the aluminum or zinc casting parts using in LED Underwater Light area.
In the die casting process,higher specific pressure is required, so that higher filling speed can be obtained.which is beneficial for alloy to overcome mold filling resistance.and effectively fill each part of the cavity.The Casting General Tolerance is Grade GB-CT4.
Process Technology: High pressure die casting, NC Machining,Shot Blasting
Casting General Tolerance: Grade GB-CT4
Flow Processes: Die casting, Degating to remove the residual of the gate, Polishing and Deburring to remove the burrs, Polishing to remove the parting line, flash,CNC Turning, Cleaning, Packaging, Storaging, Shipping
Control Measure: Incoming Material Test, First Article inspection, Routing inspection, Final item inspection, and Outgoing quality control
Inspection Equipment: CMM, Caliper, Plug Gage, Screw Gauge
Application: Machinery Parts
Certificate: IATF16949:2016,ISO14001:2015,ISO45001:2018
Lead Time: 30-35 days
Trade Term: FOB Ningbo
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